Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds.

An extract from an African mango called Irvingia gabonensishas been shown to help support leptin sensitivity in overweight people. In a recently published study,irvingia demonstrated beneficial effects upon leptin blood levels, followed by weight loss and inches off the waistline.49 In addition tosupporting healthy leptin sensitivity, irvingia has demonstrated the following beneficial effects on key aspects of metabolism:

• Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat. Irvingia has been shown in studies involving fat cells to reduce the activity of glycerol-3-phosphate dehydrogenase,50 which may help reduce the impact of starch and sugar calories on body fat.

• Scientific research on fat cells suggests that irvingia has alpha-amylase-inhibiting properties51 (like InSea2™ and Phaseolus vulgaris) which can help support a slowing of the rate of carbohydrate absorption from the intestines and a reduction of the caloric impact of starchy and sugary foods.52

• Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Big fat cells produce less adiponectin, and overweight people need to be especially concerned about maintaining healthy levels of adiponectin to support insulin sensitivity and metabolic fitness. Scientific data suggests that irvingia helps support healthy adiponectin levels.50

Based on impressive human clinical data that supports weight loss of over 20 pounds on average in 10 weeks,49 this standalone formula of an African mango extract, Integra-Lean® Irvingia, is also available to help promote optimal weight.

Please note: This product is designed to target several critical factors involved in age-related weight gain. Those who ingest more calories than what their body has the metabolic capacity to utilize will not see results. This is because some people are ingesting so many excess calories that no matter how much their metabolic rate is increased, or how much improvement occurs in their post-meal blood sugar and serum triglyceride levels, or by how much youthful insulin sensitivity and other body fat-regulating systems are restored, they are overwhelming the metabolic capacity to utilize these calories. This will result in excess calories being stored in adipocytes. One cannot consume limitless calories and expect to shed fat pounds by taking drugs, nutrients, and/or hormones that demonstrate weight-loss effects in clinical studies.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending.